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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: XRN2 All Species: 35.15
Human Site: S199 Identified Species: 55.24
UniProt: Q9H0D6 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H0D6 NP_036387.2 950 108582 S199 T V I L S D A S A P G E G E H
Chimpanzee Pan troglodytes XP_514546 950 108522 S199 T V I L S D A S A P G E G E H
Rhesus Macaque Macaca mulatta XP_001094734 961 109718 S199 T V I L S D A S A P G E G E H
Dog Lupus familis XP_534324 950 108331 S199 T V I L S D A S A P G E G E H
Cat Felis silvestris
Mouse Mus musculus Q9DBR1 951 108669 S199 T V I L S D A S A P G E G E H
Rat Rattus norvegicus NP_001102066 561 63850
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505862 950 108030 S199 T V I L S D A S A P G E G E H
Chicken Gallus gallus Q5ZIP4 949 108524 S199 T V I L S D A S A P G E G E H
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VM71 908 103942 N201 K V I L S D A N V P G E G E H
Honey Bee Apis mellifera XP_392371 860 99367 N200 K V I L S D A N V P G E G E H
Nematode Worm Caenorhab. elegans Q9U299 975 110109 N200 E I I L S D A N V P G E G E H
Sea Urchin Strong. purpuratus XP_795068 1073 120270 N190 K V I L S D A N T P G E G E H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FQ03 1020 116807 N199 K V I L S D A N V P G E G E H
Baker's Yeast Sacchar. cerevisiae Q02792 1006 115915 T199 Q V I I S D A T V P G E G E H
Red Bread Mold Neurospora crassa Q8WZX5 1072 118291 T205 K V I I S D A T V P G E G E H
Conservation
Percent
Protein Identity: 100 99.7 97.6 98 N.A. 96 56.2 N.A. 91.1 82.9 N.A. N.A. N.A. 51.2 54 50.5 52.5
Protein Similarity: 100 99.8 98 99 N.A. 97 57.6 N.A. 95.4 90.5 N.A. N.A. N.A. 63.2 66.5 63.7 63.4
P-Site Identity: 100 100 100 100 N.A. 100 0 N.A. 100 100 N.A. N.A. N.A. 80 80 73.3 80
P-Site Similarity: 100 100 100 100 N.A. 100 0 N.A. 100 100 N.A. N.A. N.A. 86.6 86.6 86.6 86.6
Percent
Protein Identity: N.A. N.A. N.A. 42.6 40.5 40.8
Protein Similarity: N.A. N.A. N.A. 58 57.4 56.1
P-Site Identity: N.A. N.A. N.A. 80 73.3 73.3
P-Site Similarity: N.A. N.A. N.A. 86.6 86.6 86.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 94 0 47 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 94 0 0 0 0 0 0 0 0 0 % D
% Glu: 7 0 0 0 0 0 0 0 0 0 0 94 0 94 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 94 0 94 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 94 % H
% Ile: 0 7 94 14 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 80 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 34 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 94 0 0 0 0 0 % P
% Gln: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 94 0 0 47 0 0 0 0 0 0 0 % S
% Thr: 47 0 0 0 0 0 0 14 7 0 0 0 0 0 0 % T
% Val: 0 87 0 0 0 0 0 0 40 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _